Mike Tyson vs. Buster Douglas, billed as Tyson is Back!, was a professional boxing match that occurred at the Tokyo Dome on February 11, 1990. The then-undefeated, undisputed heavyweight champion Tyson lost by knockout to the 42:1 underdog Douglas. The fight is widely regarded as the biggest upset in boxing history.

Mike Tyson vs. Buster Mathis, Jr., billed as "Presumption of Innocence", was a professional boxing match contested on December 16, 1995.

A professional boxing match contested on October 25, 1990, for the WBA, WBC, and IBF heavyweight championships. The bout took place at the Mirage in Paradise, Nevada, USA and saw Douglas making the first defense of the titles he won from Mike Tyson in February 1990.

A boxing fight.

Mike Tyson vs. Carl Williams was a professional boxing match contested on July 21, 1989, for WBA, WBC, IBF and Lineal Heavyweight championships.

On January 22, 1988, Holmes was lured out of retirement to challenge reigning Undisputed World Heavyweight Champion Mike Tyson. Tyson dropped Holmes in the fourth round with an overhand right. Holmes got up, but Tyson put him down two more times in the round, and the fight was stopped. After the fight Holmes once again retired.

Bruce Seldon vs. Mike Tyson, billed as "The Championship: Part II" was a professional boxing match contested on September 7, 1996 for the WBA Heavyweight championship.

Mike Tyson’s early career was full of stunning, highlight-reel knock outs of over matched opponents. On July 26, 1986 Tyson was but four months away from becoming the youngest heavyweight champion in the history of boxing when he was pitted against Marvin Frazier, son of the man who himself had been heavyweight champion of the world 13 years prior – Smokin’ Joe Frazier. The story goes that Frazier senior had his Olympic gold medal cut into eleven pieces & then divided among his eleven children & going on the evidence of the fight video below that seems about right.

Mike Tyson vs. Andrew Golota, billed as Showdown in Motown, was a professional boxing match contested on October 20, 2000.

Mike Tyson vs. Clifford Etienne, billed as "Back to Business", was a professional boxing match contested on February 22, 2003.